054 IL-18 regulates nerve growth factor and semaphorin 3A in dermatomyositis-related pruritus

Pruritus is common in autoimmune diseases and a prominent symptom especially patients with dermatomyositis (DM). In contrast, the severity of pruritus cutaneous lupus erythematosus (CLE) less severe. Importantly, an important to differentiate DM from CLE. It has been found that keratinocytes-derived interleukin (IL)-18 played pathophysiologic role IL-18 potentially distinguishes The present study aimed investigate association IENFD DM-related possible mechanism. We was unchanged compared healthy control. Increase epidermal expression nerve growth factor (NGF) reduction semaphorin 3A (Sema3A) DM. Furthermore, induced production NGF inhibited Sema3A keratinocytes. Taken together, may contribute different itch intensity between CLE by influencing skin.